CLINICAL RESEARCH

Research Activities @ VHS

Clinical Research

Department of Clinical Research

The Department of Clinical Research was started in December 2014. The scope of the department is to conduct high quality research in translation medicine with the aim to:

Improve our understanding of the pathogenesis of various diseases

Test and develop newer treatment modalities

Improve patient handling and management

Renewal of the institute’s recognition as a Scientific and Industrial Research Organization (SIRO) from the Department of Scientific and Industrial Research (DSIR) up to the year 2020.

Scientific Advisory Committee (SAC) has been reconstituted in order to bring in technical expertise in the various medical fields.

                   

VHS Laboratory Services operating under the umbrella of the Department of Clinical Research has provided diagnostic services to 21,065 patients during the year under report for whom 2,87,784 tests have been performed. Out of the total collection, Rs. 7.72 lakhs has been given as discount. Our rates are closer to CGHS rates and the discount has been calculated from the CGHS rates. The increase in the number of patients and the collection amount in the laboratory compared to the previous year are shown in Figs. 1 and 2.

Evaluation of antibacterial, antiviral and immunomodulatory properties of plant extracts traditionally used in Siddha medicine to treat lower respiratory tract infections (LRTI)

This is an on-going project funded by the Department of Science & Technology, Government of India. In the past year, this study completed the evaluation of the antibacterial, antifungal and antiviral activities in 11 traditional herbal extracts. Of the 11 plants tested, anti-influenza viral activity was exhibited by 4 plants (Fig. 3). None of the plants exhibited antifungal activity or inhibitory activity against any of the three Gram negative bacilli tested. The three Gram positive cocci tested were inhibited by the 11 plants to some extent (Fig. 4). The anti-microbial activity is better when the numbers are lower.

           

Role of inflammatory mediators in the clinical outcome of viral warts – a pilot study.

This is a pilot study designed to generate preliminary data on the role of tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in the clinical outcome of viral warts in patients who will be treated with intralesional injections of the MMR vaccine. Though the intralesional injections of the cheaper vaccines are routinely followed in developing countries, their mechanism of action is poorly understood. This study will provide insights into this mechanism.

Multi-drug resistance (MDR) among clinical isolates in a multi-speciality hospital - a retrospective study.

This is a retrospective study proposal to analyse the microbiological data of the clinical samples submitted to the VHS Laboratory from May 2016 to July 2017. The aim of the study is to delineate the multi-drug resistance (MDR) pattern among bacteria isolated from clinical specimens in a multi-specialty hospital. The significance of the study is to throw light on to the emerging microbes within the hospital environment, which would facilitate the hospital’s Infection Control Committee to take necessary actions especially regarding the antibiotic policy.

Role of inflammasomes in Multi-Drug Resistant (MDR) bacterial infections.

A pilot study on the role of inflammasomes in multi-drug resistant (MDR) bacterial infection was proposed to generate preliminary data on the levels of innate immunity cytokine, IL-l beta. The data generated will be utilized in grant proposals that will be sent to funding agencies.

Priya K. Superbugs: emerging multi-drug resistant bacteria that pose medical challenges. Science City News Letter 2017; IX(8): 2-6.

Huey DD, Bolon B, La Perle KMD, Kannian P, Jacobson S, Ratner L, Green PL, Niewiesk S. Role of wild-type and recombinant human T-cell leukemia viruses in lymphoproliferative disease in humanized NSG mice. Comp med 2018; 68(1): 4-14.

Department of Neurosurgery (Dr. A. Lakshmipathi Neurological Centre)

Krishnan SS, Nigam P, Bachh O, Vasudevan MC. Quad Fever: Treatment through Lowering of Ambient Temperature. Indian J Crit Care Med. 2018 Jan;22(1):43-45. doi: 10.4103/ijccm.IJCCM_295_17.

Krishnan SS, Patel BR, Vasudevan MC Concurrent Multilevel Spinal Intra-medullary with Extensive Intracranial Tuberculomas: A Rare Case Report. Asian J Neurosurg. 2017 Oct-Dec;12(4):774-778. doi: 10.4103/1793-5482.185073.

Vasudevan MC, Kameswaran M, Devareddy G, Amarnath D, Krishnan SS. A rare case of an internal acoustic meatal tuberculoma involving the VII-VIII nerve complex.Neurol India. 2017 May-Jun;65(3):658-660. doi: 10.4103

Goyal S, Krishnan SS, Kameswaran M, Vasudevan MC, Ranjith, Natarajan K. Does cerebellar flocculus size affect subjective outcomes in pediatric auditory brainstem implantation. Int J Pediatr Otorhinolaryngol. 2017 Jun; 97:30-34. doi: 10.1016/j.ijporl.2017.03.027. Epub 2017 Mar 22.

Chidambaram S, Vasudevan MC, Nair MN, Joyce C, Germanwala AV.Impact of Operating Room Environment on Postoperative Central Nervous System Infection in a Resource-Limited Neurosurgical Center in South Asia.World Neurosurg. 2018 Feb; 110:e239-e244. doi: 10.1016/j.wneu.2017.10.142. Epub 2017 Nov 22

Department of Psychiatry

1. CASP- An intervention to reduce suicide among Refugees – International Journal of Social Psychiatry (Published during 2017-18)

2. Is Hinduism Ambivalent about Suicide? (On-going research)

Department of Diabetes and TAG-VHS Diabetes Research Centre

1. CASP- An intervention to reduce suicide among Refugees – International Journal of Social Psychiatry (Published during 2017-18)

2. Is Hinduism Ambivalent about Suicide? (On-going research)

    In
    (a) Type 1 Diabetes,
    (b) Neurological conditions (stroke, - Para/quadriplegia, Parkinsonism, Cranial Nerve Palsies,
    (c) Locomotor problems – Osteoarthritis, Intervertebral Disc Prolapse etc.,
    (d) A host of various other Acute and Chronic Clinical conditions

3. EDTA Chelation and its application in Clinical Medicine
    – CVS, Severe Diabetic Poly Neuropathy, etc.
    – Statistics available vide website tagvhsdrc.com

4. Dr.Wheatgrass Spray and Balm (Gel) in wound healing diabetics and non-diabetics.

5. Paida – Lajin Therapy and its clinical application – vide website tagvhsdrc.com

6. Electrolysed Reduced alkaline Water in Health and Disease

7. Miscellaneous:

    1. Role of Ayurveda in the treatment of Diabetes Mellitus
    2. Chinese Volcanic Ash Therapy and its success in the treatment of Intractable CORNS

8. Nano Silver Socks effect in Diabetic Neuropathy. The comparative Combined effects of DAMM / PEMFE therapies in challenged children (Autism / MR)

Dr. A. Lakshmipathi Research Centre for Ayurveda (CCRAS)

Dr. Achanta Lakshmipathi Research Centre for Ayurveda started functioning as a grant-in-aid unit from 1st February, 1965 under the auspices of the Central Council for Ayurvedic Research of the Ministry of Ayush, Govt. of India. According to the new mandate i.e., Clinical research on life-style related and non-communicable diseases, the various activities of the Centre have highlighted in brief as below.

Out Patient Department: A total number of 2615 patients were treated, out of which 946 were male, 1669 were female. In geriatric OPD a total number of 560 patients were being benefited by taking the treatment out of which, 106 were male and 454 were female patients. In Specialty ‘Flu like illness’ OPD a total number of 142 patients were treated in which 56 were male and 86 were female.

Clinical Research Projects: Continuing IMR Clinical trial entitled ‘Clinical evaluation of Sukumara Ghritam and Brahmi Churnam in the management of Menopausal Syndrome” in which total number of 18 patients were screened, 17 participants have been enrolled along with 6 patients who have completed the trial.

Doctors

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